Anatomy Shared Article Research

This blog exists for the Anatomy students at Tree of Life Christian School. We will be reading various scientific articles, summarizing our research, and then commenting on others' summaries. We hope to broaden our view of the current research surrounding the human body, and to help others see how truly amazing the design of the human body is.

Monday, October 15, 2007

Can we have too much water?

ARTICLE...
Liquid H
2O is the sine qua non of life. Making up about 66 percent of the human body, water runs through the blood, inhabits the cells, and lurks in the spaces between. At every moment water escapes the body through sweat, urination, defecation or exhaled breath, among other routes. Replacing these lost stores is essential but rehydration can be overdone. There is such a thing as a fatal water overdose. Earlier this year, a 28-year-old California woman died after competing in a radio station's on-air water-drinking contest. After downing some six liters of water in three hours in the "Hold Your Wee for a Wii" (Nintendo game console) contest, Jennifer Strange vomited, went home with a splitting headache, and died from so-called water intoxication. There are many other tragic examples of death by water. In 2005 a fraternity hazing at California State University, Chico, left a 21-year-old man dead after he was forced to drink excessive amounts of water between rounds of push-ups in a cold basement. Club-goers taking MDMA ("ecstasy") have died after consuming copious amounts of water trying to rehydrate following long nights of dancing and sweating. Going overboard in attempts to rehydrate is also common among endurance athletes. A 2005 study in the New England Journal of Medicine found that close to one sixth of marathon runners develop some degree of hyponatremia, or dilution of the blood caused by drinking too much water. Hyponatremia, a word cobbled together from Latin and Greek roots, translates as "insufficient salt in the blood." Quantitatively speaking, it means having a blood sodium concentration below 135 millimoles per liter, or approximately 0.4 ounces per gallon, the normal concentration lying somewhere between 135 and 145 millimoles per liter. Severe cases of hyponatremia can lead to water intoxication, an illness whose symptoms include headache, fatigue, nausea, vomiting, frequent urination and mental disorientation. In humans the kidneys control the amount of water, salts and other solutes leaving the body by sieving blood through their millions of twisted tubules. When a person drinks too much water in a short period of time, the kidneys cannot flush it out fast enough and the blood becomes waterlogged. Drawn to regions where the concentration of salt and other dissolved substances is higher, excess water leaves the blood and ultimately enters the cells, which swell like balloons to accommodate it. Most cells have room to stretch because they are embedded in flexible tissues such as fat and muscle, but this is not the case for neurons. Brain cells are tightly packaged inside a rigid boney cage, the skull, and they have to share this space with blood and cerebrospinal fluid, explains Wolfgang Liedtke, a clinical neuroscientist at Duke University Medical Center. "Inside the skull there is almost zero room to expand and swell," he says. Thus, brain edema, or swelling, can be disastrous. "Rapid and severe hyponatremia causes entry of water into brain cells leading to brain swelling, which manifests as seizures, coma, respiratory arrest, brain stem herniation and death," explains M. Amin Arnaout, chief of nephrology at Massachusetts General Hospital and Harvard Medical School. Where did people get the idea that guzzling enormous quantities of water is healthful? A few years ago Heinz Valtin, a kidney specialist from Dartmouth Medical School, decided to determine if the common advice to drink eight, eight-ounce glasses of water per day could hold up to scientific scrutiny. After scouring the peer-reviewed literature, Valtin concluded that no scientific studies support the "eight x eight" dictum (for healthy adults living in temperate climates and doing mild exercise). In fact, drinking this much or more "could be harmful, both in precipitating potentially dangerous hyponatremia and exposure to pollutants, and also in making many people feel guilty for not drinking enough," he wrote in his 2002 review for the American Journal of Physiology—Regulatory, Integrative and Comparative Physiology. And since he published his findings, Valtin says, "not a single scientific report published in a peer-reviewed publication has proven the contrary." Most cases of water poisoning do not result from simply drinking too much water, says Joseph Verbalis, chairman of medicine at Georgetown University Medical Center. It is usually a combination of excessive fluid intake and increased secretion of vasopression (also called antidiuretic hormone), he explains. Produced by the hypothalamus and secreted into the bloodstream by the posterior pituitary gland, vasopressin instructs the kidneys to conserve water. Its secretion increases in periods of physical stress—during a marathon, for example—and may cause the body to conserve water even if a person is drinking excessive quantities. Every hour, a healthy kidney at rest can excrete 800 to 1,000 milliliters, or 0.21 to 0.26 gallon, of water and therefore a person can drink water at a rate of 800 to 1,000 milliliters per hour without experiencing a net gain in water, Verbalis explains. If that same person is running a marathon, however, the stress of the situation will increase vasopressin levels, reducing the kidney's excretion capacity to as low as 100 milliliters per hour. Drinking 800 to 1,000 milliliters of water per hour under these conditions can potentially lead a net gain in water, even with considerable sweating, he says. While exercising, "you should balance what you're drinking with what you're sweating," and that includes sports drinks, which can also cause hyponatremia when consumed in excess, Verbalis advises. "If you're sweating 500 milliliters per hour, that is what you should be drinking." But measuring sweat output is not easy. How can a marathon runner, or any person, determine how much water to consume? As long as you are healthy and equipped with a thirst barometer unimpaired by old age or mind-altering drugs, follow Verbalis's advice, "drink to your thirst. It's the best indicator."


SUMMARY...
This article talks about how people used to think that you can never get enough water but in reality you can definitely get too much water. Many people have died because they have been trying to rehydrate themselves and they over hydrate. What happens is the kidneys can't work fast enough to flush it all out and you can get water intoxication and you can get nausea, fatigue, dizziness or even die. The water goes everywhere in the body and the cells start to swell. Most cells in your body can handle this but when the cells in your skull swell and there isn't room for cells to get bigger around your brain. When the cells surrounding your brain become hypotonic it can cause severe problems and bad swelling.


MY OPINION...
I didn't know that people could actually die because of drinking too much water! It's amazing that God created thirst and how we know when our body needs water and we know when to stop. It is important that we listen to our bodies and trust what their telling us because they know what they need. Our body has such an amazing balance and it's neat to think about how just one little thing like too much or too little water will throw everything off. I really enjoyed this article and learned a lot about how our bodies rely on water.

4 Comments:

Blogger Señor Awesome said...

I've heard it said that anything in excess is bad. Well, this article reinforces that fact. The human body needs many things to be in balance all at once to maintain homeostasis, not the least of which is water. Most people, however, only think about a lack of water. This article shows that we must also be careful not to take in exorbitant amounts of water.

Tuesday, October 16, 2007 8:24:00 PM  
Blogger kati ware said...

This article reminds me of the statement:"You should never have too much of anything." It is amazing how God has equipped our bodies with natural "homeostatic alarms". When we need water, we are thirsty; and when we have fully hydrated our body, the feeling of thirst stops.

Wednesday, October 17, 2007 5:07:00 PM  
Blogger Kaylee said...

If too much water is bad for you, then why do health nuts still tell people to drink eight glasses of water everyday? This article proves that you can't drink eight glasses a day without getting sick, so why do people still try? I am so glad God built a warning system into our bodies!

Thursday, October 18, 2007 10:41:00 AM  
Blogger bigbenrocksmyworld said...

I have taken part in many sports and been told over and over that the more your outside and running the more you should drink. This article definately disproves this but says to stay hydrated before you go outside and then just drink to your thirst. This in itself is an amazing thing that your body measures how much you should drink with a feeling. It is interesting though that the more active you are the less vasopressin is secreted causing you to retain water to keep your body cool its amazing.

Tuesday, October 23, 2007 3:52:00 PM  

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